[Pilot Project: Improved Lung Deposition via a New Nasal Inhalation Procedure].

Mursina, L; Groß, V; Librizzi, D; Luster, M; Sohrabi, A; Seifert, O; Hildebrandt, O; Heverhagen, Johannes; Koehler, U; Sohrabi, K (2015). [Pilot Project: Improved Lung Deposition via a New Nasal Inhalation Procedure]. Pneumologie, 69(8), pp. 469-476. Thieme 10.1055/s-0034-1392444

[img]
Preview
Text
s-0034-1392444.pdf - Published Version
Available under License Publisher holds Copyright.

Download (522kB) | Preview

INTRODUCTION Inhaled drugs can only be effective if they reach the middle and small airways. This study introduces a system that combines a trans-nasal application of aerosols with noninvasive pressure support ventilation. METHODS In a pilot study, 7 COPD patients with GOLD stages II and III inhaled a radiolabeled marker dissolved in water via a trans-nasal route. The mean aerosol particle size was 5.5 µm. Each patient took part in two inhalation sessions that included two application methods and were at least 70 hours apart. During the first session ("passive method"), the patient inhaled the aerosol through an open tube system. The second session ("active method") included pressure support ventilation during the inhalation process. A gamma camera and planar scintigraphy was used to determine the distribution of aerosol particles in the patient's body and lung. RESULTS The pressure supported inhalation ("active method") results in an increased aerosol lung deposition compared to the passive method. Above all, we could demonstrate deposition in the lung periphery with relatively large aerosol particles (5.5 µm). DISCUSSION The results prove that the combination of trans-nasal inhalation with noninvasive pressure support ventilation leads to significantly increased particle deposition in the lung.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Heverhagen, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0934-8387

Publisher:

Thieme

Language:

German

Submitter:

Aisha Stefania Mzinga

Date Deposited:

23 Mar 2016 12:19

Last Modified:

08 Nov 2016 13:35

Publisher DOI:

10.1055/s-0034-1392444

PubMed ID:

26258421

BORIS DOI:

10.7892/boris.77394

URI:

https://boris.unibe.ch/id/eprint/77394

Actions (login required)

Edit item Edit item
Provide Feedback