Host-derived biomarkers at teeth and implants in partially edentulous patients. A 10-year retrospective study.

Ramseier, Christoph Andreas; Eick, Sigrun; Brönnimann, Claudia; Buser, Daniel; Brägger, Urs; Salvi, Giovanni Edoardo (2016). Host-derived biomarkers at teeth and implants in partially edentulous patients. A 10-year retrospective study. Clinical oral implants research, 27(2), pp. 211-217. Wiley-Blackwell 10.1111/clr.12566

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OBJECTIVES To assess a selection of host-derived biomarkers in peri-implant sulcus fluid (PISF) and gingival crevicular fluid (GCF) from adjacent teeth 10 years following implant placement. MATERIAL AND METHODS Peri-implant sulcus fluid and GCF samples obtained from the deepest sites of 504 implants and 493 adjacent teeth were analysed for levels of interleukin (IL)-1β, matrix metalloproteinase (MMP)-3, MMP-8, MMP-1, and MMP-1 bound to tissue inhibitor of MMP (TIMP)-1 (MMP-1/TIMP-1) by enzyme-linked immunosorbent assay (ELISA) technique. RESULTS Overall, MMP-8 was detected in 90% of the sites. In more than 50% of the sites, IL-1β was identified while in 30% of the sites MMP-1, MMP-1/TIMP-1 and MMP-3 were found over the detection level. Increased biomarkers levels from PISF and GCF were positively correlated (r = 0.375-0.702; P < 0.001). However, no qualitative and quantitative differences were found between PISF and GCF. The levels of MMP-1 were negatively correlated with those of MMP-1/TIMP-1 at implants (r = -0.644; P < 0.001). Median MMP-1 levels at implants were high (5.17 pg/site) in subjects with severe chronic periodontitis and low in patients with mild-to-moderate chronic periodontitis (0 pg/site; P = 0.026) or gingivitis (0 pg/site; P = 0.034). Levels of IL-1β were found to be different in GCF according to the periodontal conditions (P = 0.001) with the highest level found in mild-to-moderate periodontitis (6.2 pg/site). Clinical attachment levels at implants demonstrated an inverse correlation with MMP-1/TIMP-1 (r = -0.147; P = 0.001). CONCLUSIONS Increased levels of MMP-8 and IL-1β in PISF or GCF may be associated with inflammation around teeth and implants while lower levels of MMP-1/TIMP-1 may be an indicator of disease progression around implants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Ramseier, Christoph Andreas; Eick, Sigrun; Buser, Daniel; Brägger, Urs and Salvi, Giovanni Edoardo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-7161

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

07 Apr 2016 09:34

Last Modified:

14 Sep 2017 12:40

Publisher DOI:

10.1111/clr.12566

PubMed ID:

25682848

Uncontrolled Keywords:

biomarkers, dental implants, gingival crevicular fluid, host response, peri-implant mucositis, peri-implant sulcus fluid, peri-implantitis

BORIS DOI:

10.7892/boris.77415

URI:

https://boris.unibe.ch/id/eprint/77415

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