New developments providing mechanistic insight into the impact of the microbiota on allergic disease

McCoy, Kathleen; Köller, Yasmin (2015). New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clinical immunology, 159(2), pp. 170-176. Elsevier 10.1016/j.clim.2015.05.007

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The increase in allergic diseases over the past several decades is correlated with changes in the composition and diversity of the intestinal microbiota. Microbial-derived signals are critical for instructing the developing immune system and conversely, immune regulation can impact the microbiota. Perturbations in the microbiota composition may be especially important during early-life when the immune system is still developing, resulting in a critical window of opportunity for instructing the immune system. This review highlights recent studies investigating the role of the microbiome in susceptibility or development of allergic diseases with a focus on animal models that provide insight into the mechanisms and pathways involved. Identification of a causal link between reduced microbial diversity or altered microbial composition and increased susceptibility to immune-mediated diseases will hopefully pave the way for better preventive therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

McCoy, Kathleen and Köller, Yasmin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1521-6616

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

30 Mar 2016 09:36

Last Modified:

15 May 2016 12:09

Publisher DOI:

10.1016/j.clim.2015.05.007

PubMed ID:

25988860

Uncontrolled Keywords:

Allergy; Germ-free; IgE; Immune regulation; Microbiota

BORIS DOI:

10.7892/boris.77488

URI:

https://boris.unibe.ch/id/eprint/77488

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