The bilateral responsiveness between intestinal microbes and IgA

Macpherson, Andrew; Köller, Yasmin; McCoy, Kathleen (2015). The bilateral responsiveness between intestinal microbes and IgA. Trends in immunology, 36(8), pp. 460-470. Elsevier 10.1016/j.it.2015.06.006

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The immune system has developed strategies to maintain a homeostatic relationship with the resident microbiota. IgA is central in holding this relationship, as the most dominant immunoglobulin isotype at the mucosal surface of the intestine. Recent studies report a role for IgA in shaping the composition of the intestinal microbiota and exploit strategies to characterise IgA-binding bacteria for their inflammatory potential. We review these findings here, and place them in context of the current understanding of the range of microorganisms that contribute to the IgA repertoire and the pathways that determine the quality of the IgA response. We examine why only certain intestinal microbes are coated with IgA, and discuss how understanding the determinants of this specific responsiveness may provide insight into diseases associated with dysbiosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Macpherson, Andrew; Köller, Yasmin and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-4906

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

30 Mar 2016 09:12

Last Modified:

07 Nov 2016 09:53

Publisher DOI:

10.1016/j.it.2015.06.006

PubMed ID:

26169256

Uncontrolled Keywords:

IgA; Peyer's patch; commensal microbiota; follicular dendritic cells; follicular helper T cells; follicular regulatory T cells; germinal centres; isolated lymphoid follicles; somatic hypermutation

BORIS DOI:

10.7892/boris.77489

URI:

https://boris.unibe.ch/id/eprint/77489

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