Severe postoperative wound healing disturbance in a patient with alpha-1-antitrypsin deficiency: the impact of augmentation therapy

Cathomas, Marionna Myrta; Schüller, Alexandra; Candinas, Daniel; Inglin, Roman (2015). Severe postoperative wound healing disturbance in a patient with alpha-1-antitrypsin deficiency: the impact of augmentation therapy. International wound journal, 12(5), pp. 601-604. Blackwell Publishing 10.1111/iwj.12419

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Wound healing disturbance is a common complication following surgery, but the underlying cause sometimes remains elusive. A 50-year-old Caucasian male developed an initially misunderstood severe wound healing disturbance following colon and abdominal wall surgery. An untreated alpha-1-antitrypsin (AAT) deficiency in the patient's medical history, known since 20 years and clinically apparent as a mild to moderate chronic obstructive pulmonary disease, was eventually found to be at its origin. Further clinical work-up showed AAT serum levels below 30% of the lower reference value; phenotype testing showed a ZZ phenotype and a biopsy taken from the wound area showed the characteristic, disease-related histological pattern of necrotising panniculitits. Augmentation therapy with plasma AAT was initiated and within a few weeks, rapid and adequate would healing was observed. AAT deficiency is an uncommon but clinically significant, possible cause of wound healing disturbances. An augmentation therapy ought to be considered in affected patients during the perioperative period.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Cathomas, Marionna Myrta; Schüller, Alexandra; Candinas, Daniel and Inglin, Roman

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1742-4801

Publisher:

Blackwell Publishing

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

30 Mar 2016 10:17

Last Modified:

14 Oct 2019 11:36

Publisher DOI:

10.1111/iwj.12419

PubMed ID:

25818083

Uncontrolled Keywords:

Alpha-1-antitrypsin deficiency; Laparotomy; Panniculitis; Postoperative; Surgery; Wound healing disturbance

BORIS DOI:

10.7892/boris.77503

URI:

https://boris.unibe.ch/id/eprint/77503

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