Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention

Chang, Aeson; Kim-Fuchs, Corina; Le, Caroline P; Hollande, Frédéric; Sloan, Erica K (2015). Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention. Cancers, 7(3), pp. 1292-1312. MDPI AG 10.3390/cancers7030838

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The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages of tumor progression and dissemination, and contributes to its associated low survival rates. Several molecular factors that regulate interactions between pancreatic tumors and their surrounding stroma are beginning to be identified. Yet broader physiological factors that influence these interactions remain unclear. Here, we discuss a series of preclinical and mechanistic studies that highlight the important role chronic stress plays as a physiological regulator of neural-tumor interactions in driving the progression of pancreatic cancer. These studies propose several approaches to target stress signaling via the β-adrenergic signaling pathway in order to slow pancreatic tumor growth and metastasis. They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Kim-Fuchs, Corina

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

30 Mar 2016 10:37

Last Modified:

13 Sep 2017 02:29

Publisher DOI:

10.3390/cancers7030838

PubMed ID:

26193320

Uncontrolled Keywords:

pancreatic cancer; beta-adrenergic; stress; beta-blockers; neural; metastasis

BORIS DOI:

10.7892/boris.77509

URI:

https://boris.unibe.ch/id/eprint/77509

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