Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

Haas, Anna; Zimmermann, Kathrin; Graw, Frederik; Slack, Emma; Rusert, Peter; Ledergerber, Bruno; Bossart, Walter; Weber, Rainer; Thurnheer, Maria C; Battegay, Manuel; Hirschel, Bernard; Vernazza, Pietro; Patuto, Nicola; Macpherson, Andrew J; Günthard, Huldrych F; Oxenius, Annette; Swiss HIV Cohort Study, (2011). Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection. Gut, 60(11), pp. 1506-19. London: BMJ Publishing Group 10.1136/gut.2010.224774

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Human systemic antibody responses to commensal microbiota are not well characterised during health and disease. Of particular interest is the analysis of their potential modulation caused by chronic HIV-1 infection which is associated with sustained enteropathy and systemic B cell disturbances reflected by impaired B cell responses and chronic B cell hyperactivity. The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Raio, Luigi; Thurnheer Zürcher, Maria Christine and Macpherson, Andrew




BMJ Publishing Group




Factscience Import

Date Deposited:

04 Oct 2013 14:22

Last Modified:

17 Mar 2015 21:01

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URI: (FactScience: 213082)

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