Home parenteral nutrition is beneficial in systemic sclerosis patients with gastrointestinal dysfunction

Stanga, Zeno Giovanni; Aeberhard, C; Schärer, P; Kocher, A; Adler, Sabine; Villiger, Peter (2015). Home parenteral nutrition is beneficial in systemic sclerosis patients with gastrointestinal dysfunction. Scandinavian journal of rheumatology, 45(1), pp. 32-35. Informa Healthcare 10.3109/03009742.2015.1064543

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OBJECTIVES To assess 12-month changes in nutritional status and quality of life (QoL) in systemic sclerosis (SSc) patients requiring home parenteral nutrition (HPN). METHOD We conducted a retrospective, single-centre database analysis of SSc patients regarding a 12-month period of HPN at an interdisciplinary University Unit/team for nutrition and rheumatic diseases. Nutritional status was analysed by nutritional risk screening (NRS) and body mass index (BMI). QoL was evaluated using Short-Form Health Survey (SF-36) questionnaires. RESULTS Between 2008 and 2013, daily nocturnal HPN was initiated in five consecutive SSc patients (four females and one male, mean age 62.2 years) suffering severe malnutrition due to gastrointestinal tract (GIT) involvement. After 12 months of HPN, the mean NRS score decreased from 4.4 (range 4-5) to 1.4 (range 1-2), the mean BMI increased from 19.1 (range 17.4-20.3) to 21.0 kg/m(2) (range 18.3-23.4). QoL improved in all patients, reflected by the summary of physical components with 33.92 points before vs. 67.72 points after 12 months of HPN, and the summary of mental components with 49.66 points before vs. 89.27 points after 12 months of HPN. Two patients suffered one catheter-related infection each with subsequent surgical removal and reinsertion. CONCLUSIONS HPN is a feasible method for improving anthropometric parameters and QoL in SSc patients severely affected by GIT dysfunction. We recommend HPN in malnourished, catabolic SSc patients unable to otherwise maintain or improve their nutritional status.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

UniBE Contributor:

Stanga, Zeno Giovanni; Adler, Sabine and Villiger, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0300-9742

Publisher:

Informa Healthcare

Language:

English

Submitter:

Markus Laimer

Date Deposited:

30 Mar 2016 13:30

Last Modified:

11 Apr 2016 14:59

Publisher DOI:

10.3109/03009742.2015.1064543

PubMed ID:

26303230

URI:

https://boris.unibe.ch/id/eprint/77618

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