Cryopreservation and transplantation of ovarian tissue exclusively to postpone menopause: technically possible but endocrinologically doubtful.

von Wolff, Michael; Stute, Petra (2015). Cryopreservation and transplantation of ovarian tissue exclusively to postpone menopause: technically possible but endocrinologically doubtful. Reproductive biomedicine online, 31(6), pp. 718-721. Elsevier 10.1016/j.rbmo.2015.08.010

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Transplantation of cryopreserved ovarian tissue has been shown to induce pregnancies and puberty successfully. Therefore, using cryopreserved ovarian tissue to postpone menopause (tissue hormone therapy [THT]) seems to be an interesting option to avoid conventional menopause hormone therapy (MHT). Pregnancy induction and replacing MHT by THT, however, are completely different topics as different requirements need to be met. First, MHT requires long-lasting and continuous hormone production. It still needs to be proven if the transplanted tissue is active for at least 5 years with a continuous follicle growth to avoid phases with low oestrogen production, which would otherwise cause menopausal symptoms and could reduce the postulated benefit for women's health. Second, the advantage of a physiological hormone production over a non-physiological MHT is still hypothetical. Third, women who have undergone hysterectomies who do not need progesterone for endometrial protection would only require oestrogens, imposing more health benefits (cardiovascular system, mammary gland) than oestrogen and progesterone production or replacement. Therefore, transplanting ovarian tissue exclusively to postpone menopause is endocrinologically doubtful and should only be carried out within clinical trials.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

von Wolff, Michael and Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1472-6483

Publisher:

Elsevier

Language:

English

Submitter:

Monika Zehr

Date Deposited:

17 Feb 2016 16:45

Last Modified:

11 Sep 2017 21:20

Publisher DOI:

10.1016/j.rbmo.2015.08.010

PubMed ID:

26380862

Uncontrolled Keywords:

cryopreservation; menopausal hormone therapy; menopause; ovarian tissue; transplantation

BORIS DOI:

10.7892/boris.77662

URI:

https://boris.unibe.ch/id/eprint/77662

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