Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype

Gutiérrez, Ana; Holler, Ernst; Zapater, Pedro; Sempere, Laura; Jover, Rodrigo; Pérez-Mateo, Miguel; Schoelmerich, Juergen; Such, José; Wiest, Reiner; Francés, Rubén (2011). Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype. Inflammatory bowel diseases, 17(8), pp. 1641-50. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1002/ibd.21537

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Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/CARD15. The aim was to test whether defensins and cathelicidin (LL-37) expression and NOD2/CARD15 mutations in blood neutrophils are related to molecular bacterial translocation events in CD patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Wiest, Reiner

ISSN:

1078-0998

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

17 Mar 2015 21:01

Publisher DOI:

10.1002/ibd.21537

PubMed ID:

21744420

Web of Science ID:

000293235400018

URI:

https://boris.unibe.ch/id/eprint/7767 (FactScience: 213093)

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