Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction

Moleda, Lukas; Trebicka, Jonel; Dietrich, Peter; Gäbele, Erwin; Hellerbrand, Claus; Straub, Rainer H; Sauerbruch, Tilman; Schoelmerich, Juergen; Wiest, Reiner (2011). Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction. Gut, 60(8), pp. 1122-32. London: BMJ Publishing Group 10.1136/gut.2010.226407

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Splanchnic vasodilation triggers the development of the hyperdynamic circulatory syndrome in portal hypertension. Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats. Therefore, we investigated the effect of NPY on mesenteric arterial contractility in vitro and in vivo in cirrhotic ascitic rats, as well as the vasoactive pathways involved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Wiest, Reiner

ISSN:

0017-5749

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

06 Dec 2013 13:28

Publisher DOI:

10.1136/gut.2010.226407

PubMed ID:

21317421

Web of Science ID:

000292318200019

URI:

https://boris.unibe.ch/id/eprint/7771 (FactScience: 213097)

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