Hepatocellular carcinoma and lifestyles.

Saran, Uttara; Humar, Bostjan; Kolly, Philippe; Dufour, Jean-François (2016). Hepatocellular carcinoma and lifestyles. Journal of hepatology, 64(1), pp. 203-214. Elsevier 10.1016/j.jhep.2015.08.028

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The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and hepatocellular carcinoma has become evident. Abundance of energy-rich food and sedentary lifestyles have caused metabolic conditions such as obesity and diabetes mellitus to become global epidemics. Obesity and diabetes mellitus are both tightly linked to non-alcoholic fatty liver disease and also increase hepatocellular carcinoma risk independent of cirrhosis. Emerging data suggest that physical activity not only counteracts obesity, diabetes mellitus and non-alcoholic fatty liver disease, but also reduces cancer risk. Physical activity exerts significant anticancer effects in the absence of metabolic disorders. Here, we present a systematic review on lifestyles and hepatocellular carcinoma.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Saran, Uttara; Kolly, Philippe and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0168-8278

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

08 Apr 2016 09:49

Last Modified:

08 Apr 2016 14:19

Publisher DOI:

10.1016/j.jhep.2015.08.028

PubMed ID:

26341826

Uncontrolled Keywords:

AMPK; Diabetes; Exercise; Insulin; Liver cancer; Obesity mTOR

BORIS DOI:

10.7892/boris.77719

URI:

https://boris.unibe.ch/id/eprint/77719

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