Portal levels of latent transforming growth factor-β are related to liver function in patients with liver cirrhosis

Wanninger, Josef; Wiest, Reiner; Bauer, Sabrina; Neumeier, Markus; Eisinger, Kristina; Farkas, Stefan; Scherer, Marcus N; Schäffler, Andreas; Buechler, Christa (2011). Portal levels of latent transforming growth factor-β are related to liver function in patients with liver cirrhosis. European journal of gastroenterology & hepatology, 23(3), pp. 218-23. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MEG.0b013e328343700a

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Transforming growth factor-β1 (TGFβ1) is a short-lived immune suppressive and profibrotic protein. Its latent precursor is relatively stable and may even protect from fibrosis. Latent TGFβ1 is synthesized by various tissues including the liver and portal, hepatic, and systemic concentrations of latent TGFβ1 were determined in patients with liver cirrhosis and patients with normal liver function to find out whether circulating levels are affected by liver disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Wiest, Reiner

ISSN:

0954-691X

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

17 Mar 2015 21:01

Publisher DOI:

10.1097/MEG.0b013e328343700a

PubMed ID:

21228704

Web of Science ID:

000287131600004

URI:

https://boris.unibe.ch/id/eprint/7772 (FactScience: 213098)

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