First-Trimester Placental Growth Factor in Screening for Gestational Diabetes.

Mosimann, Beatrice; Amylidi, Sofia Kalypso; Risch, Lorenz; Wiedemann, Ute; Surbek, Daniel; Baumann, Marc Ulrich; Stettler, Christoph; Raio, Luigi (2015). First-Trimester Placental Growth Factor in Screening for Gestational Diabetes. Fetal diagnosis and therapy, 39(4), pp. 287-291. Karger 10.1159/000441027

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OBJECTIVE The aim of this study was first to assess whether first-trimester serum concentrations of placental growth factor (PlGF) differ between patients with and without gestational diabetes (GDM) and second to test whether there is a correlation between glycosylated hemoglobin (HbA1c), a factor recently shown to be useful in predicting GDM, and PlGF. METHODS PlGF was measured at 8-14 weeks with the Kryptor Immunoassay Analyzer (Brahms, Berlin, Germany). Absolute values were converted to multiples of the median using the software provided by the Fetal Medicine Foundation London. GDM was diagnosed using internationally accepted criteria. HbA1c levels were quantified using the TOSOH G7 automated hemoglobin analyzer. RESULTS From January to December 2014, 328 women were included in the study, 51 (15.5%) of whom developed GDM. First-trimester PlGF quantification does not discriminate between women at risk to develop GDM and controls, while HbA1c is able to do so. No correlation was found between PlGF and HbA1c. CONCLUSION Our findings do not lend support to the hypothesis that early PlGF values are different in women who later develop GDM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Mosimann, Beatrice; Amylidi, Sofia Kalypso; Surbek, Daniel; Baumann, Marc Ulrich; Stettler, Christoph and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1015-3837

Publisher:

Karger

Language:

English

Submitter:

Monika Zehr

Date Deposited:

04 Mar 2016 09:11

Last Modified:

01 Jun 2017 02:30

Publisher DOI:

10.1159/000441027

PubMed ID:

26421599

BORIS DOI:

10.7892/boris.77766

URI:

https://boris.unibe.ch/id/eprint/77766

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