First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes.

Amylidi, Sofia Kalypso; Mosimann, Beatrice; Stettler, Christoph; Fiedler, Martin; Surbek, Daniel; Raio, Luigi (2016). First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes. Acta obstetricia et gynecologica Scandinavica, 95(1), pp. 93-97. Wiley-Blackwell 10.1111/aogs.12784

[img] Text
aogs12784.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (233kB) | Request a copy

INTRODUCTION Our aim was to investigate the prognostic value of first-trimester glycosylated hemoglobin (HbA1c) in pregnant women with risk factors for developing gestational diabetes mellitus (GDM). MATERIAL AND METHODS This is an observational retrospective cohort study conducted at the Department of Obstetrics and Gynecology, University Hospital Bern, Switzerland. We included pregnant women at high risk for GDM (n = 208), who had an HbA1c measurement in the first trimester. We compared HbA1c values of women who later developed GDM with those who did not develop GDM. Diagnosis of GDM was made on the basis of a 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation. We further examined the prevalence of GDM in relation to the first-trimester HbA1c value. RESULTS The prevalence of GDM in our high-risk group was 14.7%. Women who developed GDM had significantly higher first-trimester HbA1c values [5.43 ± 0.31% (36 ± 3 mmol/mol) vs. 5.23 ± 0.28% (34 ± 3 mmol/mol); p = 0.0026]. Moreover, all pregnant women with HbA1c ≥6.0% (42 mmol/mol) developed GDM, whereas those with <4.5% (26 mmol/mol) did not. CONCLUSIONS Women at risk for GDM have higher first-trimester HbA1c levels and values ≥6.0% (42 mmol/mol) are predictive of GDM. This information may be useful for counseling these women and providing appropriate advice on diet and lifestyle modification early in pregnancy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Amylidi, Sofia Kalypso; Mosimann, Beatrice; Stettler, Christoph; Fiedler, Martin; Surbek, Daniel and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0001-6349

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Monika Zehr

Date Deposited:

11 Mar 2016 07:33

Last Modified:

27 Jun 2017 16:11

Publisher DOI:

10.1111/aogs.12784

PubMed ID:

26400192

Uncontrolled Keywords:

Gestational diabetes mellitus; HbA1c; glycosylated haemoglobin; high-risk pregnancy; oral glucose tolerance test

BORIS DOI:

10.7892/boris.77767

URI:

https://boris.unibe.ch/id/eprint/77767

Actions (login required)

Edit item Edit item
Provide Feedback