Placental plasticity in monochorionic twins: Impact on birth weight and placental weight

Baumann, Marc Ulrich; Marti, Michelle; Durrer, Lukas; Koumoutsakos, Petros; Angelikopoulos, Panagiotis; Bolla, Daniele Maik; Acharya, Ganesh; Bichsel, Ursina; Surbek, Daniel; Raio, Luigi (2015). Placental plasticity in monochorionic twins: Impact on birth weight and placental weight. Placenta, 36(9), pp. 1018-1023. Elsevier 10.1016/j.placenta.2015.07.120

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INTRODUCTION The knowledge about adaptive mechanisms of monochorionic placentas to fulfill the demands of two instead of one fetus is largely speculative. The aim of our study was to investigate the impact of chorionicity on birth weight and placental weight in twin pregnancies. METHODS Forty Monochorionic (MC) and 43 dichorionic (DC) twin pregnancies were included in this retrospective study. Individual and total (sum of both twins) birth weights, placental weights ratios between placental and birth weights and observed-to-expected (O/E)-ratios were calculated and analyzed. Additionally, we investigated whether in twin pregnancies placental and birth weights follow the law of allometric metabolic scaling. RESULTS MC pregnancies showed higher placental O/E-ratios than DC ones (2.25 ± 0.85 versus 1.66 ± 0.61; p < 0.05), whereas the total neonatal birth weight O/E-ratios were not different. In DC twins total placental weights correlated significantly with gestational age (r = 0.74, p < 0.001), but not in MC twins. Analysis of deliveries ≤32 weeks revealed that the placenta to birth weight ratio in MC twins was higher than in matched DC twins (0.49 ± 0.3 versus 0.24 ± 0.03; p = 0.03). Allometric metabolic scaling revealed that dichorionic twin placentas scale with birth weight, while the monochorionic ones do not. DISCUSSION The weight of MC placentas compared to that of DC is not gestational age dependent in the third trimester. Therefore an early accelerated placental growth pattern has to be postulated which leads to an excess placental mass particularly below 32 weeks of gestation. The monochorionic twins do not follow allometric metabolic scaling principle making them more vulnerable to placental compromise.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Baumann, Marc Ulrich; Bolla, Daniele Maik; Surbek, Daniel and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0143-4004

Publisher:

Elsevier

Language:

English

Submitter:

Monika Zehr

Date Deposited:

31 Mar 2016 15:46

Last Modified:

31 Mar 2016 15:46

Publisher DOI:

10.1016/j.placenta.2015.07.120

PubMed ID:

26215381

Uncontrolled Keywords:

Allometric metabolic scaling; Birth weight; Dichorionic; Fetal:placental ratio; Monochorionic; Placental weight; Twin pregnancy

BORIS DOI:

10.7892/boris.77778

URI:

https://boris.unibe.ch/id/eprint/77778

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