Does dienogest influence the inflammatory response of endometriotic cells? A systematic review.

Grandi, Giovanni; Mueller, Michael; Bersinger, Nick A.; Cagnacci, Angelo; Volpe, Annibale; Mc Kinnon, Brett (2016). Does dienogest influence the inflammatory response of endometriotic cells? A systematic review. Inflammation research, 65(3), pp. 183-192. Springer 10.1007/s00011-015-0909-7

[img] Text
art%3A10.1007%2Fs00011-015-0909-7.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (553kB) | Request a copy

OBJECTIVE AND DESIGN A systematic review of all literature was done to assess the ability of the progestin dienogest (DNG) to influence the inflammatory response of endometriotic cells. MAIN OUTCOME MEASURES In vitro and in vivo studies report an influence of DNG on the inflammatory response in eutopic or ectopic endometrial tissue (animal or human). RESULTS After strict inclusion criteria were satisfied, 15 studies were identified that reported a DNG influence on the inflammatory response in endometrial tissue. These studies identified a modulation of prostaglandin (PG) production and metabolism (PGE2, PGE2 synthase, cyclo-oxygenase-2 and microsomal PGE synthase-1), pro-inflammatory cytokine and chemokine production [interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, monocyte chemoattractant protein-1 and stromal cell-derived factor-1], growth factor biosynthesis (vascular endothelial growth factor and nerve growth factor) and signaling kinases, responsible for the control of inflammation. Evidence supports a progesterone receptor-mediated inhibition of the inflammatory response in PR-expressing epithelial cells. It also indicated that DNG inhibited the inflammatory response in stromal cells, however, whether this was via a PR-mediated mechanism is not clear. CONCLUSIONS DNG has a significant effect on the inflammatory microenvironment of endometriotic lesions that may contribute to its clinical efficacy. A better understanding of the specific anti-inflammatory activity of DNG and whether this contributes to its clinical efficacy can help develop treatments that focus on the inhibition of inflammation while minimizing hormonal modulation.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie

UniBE Contributor:

Mueller, Michael; Bersinger, Nick A. and Mc Kinnon, Brett

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1023-3830

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

14 Apr 2016 11:59

Last Modified:

15 Sep 2017 15:07

Publisher DOI:

10.1007/s00011-015-0909-7

PubMed ID:

26650031

Uncontrolled Keywords:

Chemokines, Cytokines, Dienogest, Endometriosis, Growth factors, Inflammation, Progestin, Progestogen, Prostaglandin

BORIS DOI:

10.7892/boris.77849

URI:

https://boris.unibe.ch/id/eprint/77849

Actions (login required)

Edit item Edit item
Provide Feedback