β1-integrin/matrix interactions support blood-brain barrier integrity

Engelhardt, Britta (2011). β1-integrin/matrix interactions support blood-brain barrier integrity. Journal of cerebral blood flow and metabolism, 31(10), pp. 1969-71. New York, N.Y.: Nature Publishing Group 10.1038/jcbfm.2011.98

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Brain microvascular endothelium forms an active permeability barrier, the blood-brain barrier (BBB). In neurologic disorders, barrier properties of the BBB are often lost indicating their dependance on molecular cues of the brain microenvironment. In this issue, Osada et al demonstrate that the endothelial extracellular matrix (ECM) provides one of these cues. Their study shows that β1-integrin-mediated adhesion of brain endothelial cells to the surrounding ECM is critical for stabilizing claudin-5 in BBB tight junctions (TJs) and BBB integrity. These observations point to a novel intracellular signaling pathway from β1-integrin/ECM endothelial adhesions to BBB TJs contributing to BBB integrity.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

0271-678X

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

06 Dec 2013 13:28

Publisher DOI:

10.1038/jcbfm.2011.98

PubMed ID:

21772311

Web of Science ID:

000295621600002

URI:

https://boris.unibe.ch/id/eprint/7792 (FactScience: 213128)

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