Pathogen recognition by the long pentraxin PTX3

Moalli, Federica; Jaillon, Sebastien; Inforzato, Antonio; Sironi, Marina; Bottazzi, Barbara; Mantovani, Alberto; Garlanda, Cecilia (2011). Pathogen recognition by the long pentraxin PTX3. Journal of biomedicine and biotechnology, 2011, p. 830421. Akron, Ohio: Hindawi Pub. Corp. 10.1155/2011/830421

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Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognise pathogen-associated molecular patterns (PAMPs) and initiate the immune response in coordination with the cellular arm, therefore acting as functional ancestors of antibodies. The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune cells. Gene targeting of this evolutionarily conserved protein has revealed a nonredundant role in resistance to selected pathogens. Moreover, PTX3 exerts important functions at the cross-road between innate immunity, inflammation, and female fertility. Here, we review the studies on PTX3, with emphasis on pathogen recognition and cross-talk with other components of the innate immune system.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Moalli, Federica

ISSN:

1110-7243

Publisher:

Hindawi Pub. Corp.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

05 Dec 2022 14:06

Publisher DOI:

10.1155/2011/830421

PubMed ID:

21716666

Web of Science ID:

000293554000001

BORIS DOI:

10.7892/boris.7807

URI:

https://boris.unibe.ch/id/eprint/7807 (FactScience: 213148)

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