The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling

Inforzato, A; Jaillon, S; Moalli, F; Barbati, E; Bonavita, E; Bottazzi, B; Mantovani, A; Garlanda, C (2011). The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. Tissue antigens, 77(4), pp. 271-82. Oxford: Wiley-Blackwell 10.1111/j.1399-0039.2011.01645.x

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Innate immunity represents the first line of defence against pathogens and plays key roles in the activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules that recognize pathogen-associated molecular patterns and initiate the immune response in coordination with the cellular arm, therefore acting as functional ancestors of antibodies. Pentraxins are essential constituents of the humoral arm of innate immunity and represent a superfamily of highly conserved acute phase proteins, traditionally classified into short and long pentraxins. Pentraxin 3 (PTX3) is the prototypic member of the long pentraxins subfamily. As opposed to C-reactive protein, whose sequence and regulation have not been conserved during evolution from mouse to man, the evolutionary conservation of sequence, gene organization and regulation of PTX3 has allowed addressing its pathophysiological roles in genetically modified mice, in diverse conditions, ranging from infections to sterile inflammation, angiogenesis and female fertility. Despite this conservation, a number of predominantly non-coding polymorphisms have been identified in the PTX3 gene which, when associated in particular haplotypes, have been shown to be relevant in clinical conditions including infection and fertility. Here we review the studies on PTX3, with emphasis on pathogen recognition, tissue remodelling and crosstalk with other components of the innate immune system.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
UniBE Contributor:	Moalli, Federica
ISSN:	0001-2815
Publisher:	Wiley-Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:23
Last Modified:	05 Dec 2022 14:06
Publisher DOI:	10.1111/j.1399-0039.2011.01645.x
PubMed ID:	21388349
Web of Science ID:	000288165700001
URI:	https://boris.unibe.ch/id/eprint/7809 (FactScience: 213150)