Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells

Angst, Eliane; Dawson, David W; Nguyen, Anne; Park, Jenny; Go, Vay L W; Reber, Howard A; Hines, Oscar Joe; Eibl, Guido (2010). Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas, 39(5), pp. 675-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MPA.0b013e3181c8b476

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N-myc downstream-regulated gene 1 (NDRG1), important in tumor growth and metastasis, has recently gained interest as a potential therapeutic target. Loss of NDRG1 expression is generally associated with poor clinical outcome in pancreatic cancer (PaCa) patients. As the NDRG1 gene possesses a large promoter CpG island, we sought to determine whether its repression is epigenetically mediated in PaCa cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Angst, Eliane

ISSN:

0885-3177

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.1097/MPA.0b013e3181c8b476

PubMed ID:

20173668

Web of Science ID:

000278919100021

URI:

https://boris.unibe.ch/id/eprint/784 (FactScience: 200836)

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