Tumor infiltrating lymphocytes in ovarian cancer.

Gasparri, Maria Luisa; Attar, Rukset; Palaia, Innocenza; Perniola, Giorgia; Marchetti, Claudia; Di Donato, Violante; Farooqi, Ammad Ahmad; Papadia, Andrea; Panici, Pierluigi Benedetti (2015). Tumor infiltrating lymphocytes in ovarian cancer. Asian Pacific journal of cancer prevention, 16(9), pp. 3635-3638. Asian Pacific Organization for Cancer Prevetion 10.7314/APJCP.2015.16.9.3635

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Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates. In this scenario, a pivotal role has been endorsed to the immunological environment and to the immunological mechanisms involved in ovarian cancer behavior. Recent evidence suggests a loss of the critical balance between immune-activating and immune-suppressing mechanisms when oncogenesis and cancer progression occur. Ovarian cancer generates a mechanism to escape the immune system by producing a highly suppressive environment. Immune-activated tumor infiltrating lymphocytes (TILs) in ovarian tumor tissue testify that the immune system is the trigger in this neoplasm. The TIL mileau has been demonstrated to be associated with better prognosis, more chemosensitivity, and more cases of optimal residual tumor achieved during primary cytoreduction. Nowadays, scientists are focusing attention on new immunologically effective tumor biomarkers in order to optimize selection of patients for recruitment in clinical trials and to identify relationships of these biomarkers with responses to immunotherapeutics. Assessing this point of view, TILs might be considered as a potent predictive immunotherapy biomarker.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Papadia, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1513-7368

Publisher:

Asian Pacific Organization for Cancer Prevetion

Language:

English

Submitter:

Monika Zehr

Date Deposited:

06 Apr 2016 10:03

Last Modified:

06 Apr 2016 10:03

Publisher DOI:

10.7314/APJCP.2015.16.9.3635

PubMed ID:

25987014

BORIS DOI:

10.7892/boris.78410

URI:

https://boris.unibe.ch/id/eprint/78410

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