Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

Béguelin, Charles Antoine; Vázquez, Miriam; Bertschi, Manuel; Yerly, S; de Jong, Denise; Gutbrod, Klemens; Rauch, Andri; Cusini, Alexia (2015). Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1. Open Forum Infectious Diseases, 3(1), ofv210. Oxford University Press 10.1093/ofid/ofv210

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In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Béguelin, Charles Antoine; Vázquez, Miriam; Bertschi, Manuel; de Jong, Denise; Gutbrod, Klemens; Rauch, Andri and Cusini, Alexia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2328-8957

Publisher:

Oxford University Press

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

07 Jun 2016 16:19

Last Modified:

27 Oct 2019 19:25

Publisher DOI:

10.1093/ofid/ofv210

PubMed ID:

26885540

Uncontrolled Keywords:

HIV; K65R; central nervous system; multidrug-resistant; viral escape

BORIS DOI:

10.7892/boris.78641

URI:

https://boris.unibe.ch/id/eprint/78641

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