Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia.

Sellmann, Ludger; Scholtysik, Rene; de Beer, Dirk; Eisele, Lewin; Klein-Hitpass, Ludger; Nückel, Holger; Dührsen, Ulrich; Dürig, Jan; Röth, Alexander; Baerlocher, Gabriela M. (2016). Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia. Leukemia & lymphoma, 57(3), pp. 590-595. Informa Healthcare 10.3109/10428194.2015.1076929

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This study investigated the correlation of the extent of chromosomal aberrations including uniparental disomies (UPDs) by SNP-chip analysis and FISH to telomere length in 46 patients with CLL. CLL harboring high risk aberrations, i.e. deletions of 11q22-23 or 17p13, had significantly shorter telomeres (higher ΔTL) compared to patients with CLL without such abnormalities. Patients with high chromosomal aberration rates had a worse overall survival compared to cases with lower aberration rates. Interestingly, however, an increase was found in the number of UPDs with shorter telomeres. These findings support the idea that telomeres in CLL cells play a role in the overall chromosome stability and could be involved in the occurrence of UPDs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Baerlocher, Gabriela M.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1042-8194

Publisher:

Informa Healthcare

Language:

English

Submitter:

Verena Zwahlen

Date Deposited:

23 Mar 2016 10:50

Last Modified:

26 Jun 2016 02:13

Publisher DOI:

10.3109/10428194.2015.1076929

PubMed ID:

26457386

Uncontrolled Keywords:

CLL; SNP chips; UPD; telomere length

URI:

https://boris.unibe.ch/id/eprint/78711

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