Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection

Schögler, Aline; Stokes-Luginbühl, Andrea; Casaulta Aebischer, Carmen; Regamey, Nicolas; Edwards, Michael R; Johnston, Sebastian L; Jung, Andreas; Moeller, Alexander; Geiser, Thomas; Alves, Marco (2015). Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection. Journal of cystic fibrosis, 15(3), pp. 332-339. Elsevier 10.1016/j.jcf.2015.10.013

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Rhinoviruses (RVs) are associated with exacerbations of cystic fibrosis (CF), asthma and COPD. There is growing evidence suggesting the involvement of the interferon (IFN) pathway in RV-associated morbidity in asthma and COPD. The mechanisms of RV-triggered exacerbations in CF are poorly understood. In a pilot study, we assessed the antiviral response of CF and healthy bronchial epithelial cells (BECs) to RV infection, we measured the levels of IFNs, pattern recognition receptors (PRRs) and IFN-stimulated genes (ISGs) upon infection with major and minor group RVs and poly(IC) stimulation. Major group RV infection of CF BECs resulted in a trend towards a diminished IFN response at the level of IFNs, PRRs and ISGs in comparison to healthy BECs. Contrary to major group RV, the IFN pathway induction upon minor group RV infection was significantly increased at the level of IFNs and PRRs in CF BECs compared to healthy BECs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)

UniBE Contributor:

Schögler, Aline; Stokes-Luginbühl, Andrea; Casaulta Aebischer, Carmen; Geiser, Thomas and Alves, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1569-1993

Publisher:

Elsevier

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

05 Apr 2016 15:27

Last Modified:

26 Jun 2016 02:13

Publisher DOI:

10.1016/j.jcf.2015.10.013

PubMed ID:

26613982

Uncontrolled Keywords:

Bronchial epithelial cells; Cystic fibrosis; Interferon; Rhinovirus

BORIS DOI:

10.7892/boris.78839

URI:

https://boris.unibe.ch/id/eprint/78839

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