Long-term data from the Swiss pulmonary hypertension registry.

Mueller-Mottet, Séverine; Stricker, Hans; Domenighetti, Guido; Domeninghetti, Guido; Azzola, Andrea; Geiser, Thomas; Schwerzmann, Markus; Weilenmann, Daniel; Schoch, Otto; Fellrath, Jean-Marc; Rochat, Thierry; Lador, Frederic; Beghetti, Maurice; Nicod, Laurent; Aubert, John-David; Popov, Vladimir; Speich, Rudolf; Keusch, Stephan; Hasler, Elisabeth; Huber, Lars C; ... (2015). Long-term data from the Swiss pulmonary hypertension registry. Respiration, 89(2), pp. 127-140. Karger 10.1159/000370125

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BACKGROUND Registries are important for real-life epidemiology on different pulmonary hypertension (PH) groups. OBJECTIVE To provide long-term data of the Swiss PH registry of 1998-2012. METHODS PH patients have been classified into 5 groups and registered upon written informed consent at 5 university and 8 associated hospitals since 1998. New York Heart Association (NYHA) class, 6-min walk distance, hemodynamics and therapy were registered at baseline. Patients were regularly followed, and therapy and events (death, transplantation, endarterectomy or loss to follow-up) registered. The data were stratified according to the time of diagnosis into prevalent before 2000 and incident during 2000-2004, 2005-2008 and 2009-2012. RESULTS From 996 (53% female) PH patients, 549 had pulmonary arterial hypertension (PAH), 36 PH due to left heart disease, 127 due to lung disease, 249 to chronic thromboembolic PH (CTEPH) and 35 to miscellaneous PH. Age and BMI significantly increased over time, whereas hemodynamic severity decreased. Overall, event-free survival was 84, 72, 64 and 58% for the years 1-4 and similar for time periods since 2000, but better during the more recent periods for PAH and CTEPH. Of all PAH cases, 89% had target medical therapy and 43% combination therapy. Of CTEPH patients, 14 and 2% underwent pulmonary endarterectomy or transplantation, respectively; 87% were treated with PAH target therapy. CONCLUSION Since 2000, the incident Swiss PH patients registered were older, hemodynamically better and mostly treated with PAH target therapies. Survival has been better for PAH and CTEPH diagnosed since 2008 compared with earlier diagnosis or other classifications.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Stricker, Hans; Geiser, Thomas; Schwerzmann, Markus and Tamm, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0025-7931

Publisher:

Karger

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

26 Feb 2016 16:08

Last Modified:

19 Jul 2016 15:08

Publisher DOI:

10.1159/000370125

PubMed ID:

25661477

BORIS DOI:

10.7892/boris.78848

URI:

https://boris.unibe.ch/id/eprint/78848

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