Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study.

Petrovic, Dusan; Pivin, Edward; Ponte, Belen; Dhayat, Nasser; Pruijm, Menno; Ehret, Georg; Ackermann, Daniel; Guessous, Idris; Younes, Sandrine Estoppey; Pechère-Bertschi, Antoinette; Vogt, Bruno; Mohaupt, Markus; Martin, Pierre-Yves; Paccaud, Fred; Burnier, Michel; Bochud, Murielle; Stringhini, Silvia (2016). Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study. Psychoneuroendocrinology, 67, pp. 76-85. Elsevier 10.1016/j.psyneuen.2016.02.003

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Allostatic load (AL) is a marker of physiological dysregulation which reflects exposure to chronic stress. High AL has been related to poorer health outcomes including mortality. We examine here the association of socioeconomic and lifestyle factors with AL. Additionally, we investigate the extent to which AL is genetically determined. We included 803 participants (52% women, mean age 48±16years) from a population and family-based Swiss study. We computed an AL index aggregating 14 markers from cardiovascular, metabolic, lipidic, oxidative, hypothalamus-pituitary-adrenal and inflammatory homeostatic axes. Education and occupational position were used as indicators of socioeconomic status. Marital status, stress, alcohol intake, smoking, dietary patterns and physical activity were considered as lifestyle factors. Heritability of AL was estimated by maximum likelihood. Women with a low occupational position had higher AL (low vs. high OR=3.99, 95%CI [1.22;13.05]), while the opposite was observed for men (middle vs. high OR=0.48, 95%CI [0.23;0.99]). Education tended to be inversely associated with AL in both sexes(low vs. high OR=3.54, 95%CI [1.69;7.4]/OR=1.59, 95%CI [0.88;2.90] in women/men). Heavy drinking men as well as women abstaining from alcohol had higher AL than moderate drinkers. Physical activity was protective against AL while high salt intake was related to increased AL risk. The heritability of AL was estimated to be 29.5% ±7.9%. Our results suggest that generalized physiological dysregulation, as measured by AL, is determined by both environmental and genetic factors. The genetic contribution to AL remains modest when compared to the environmental component, which explains approximately 70% of the phenotypic variance.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie

UniBE Contributor:

Dhayat, Nasser; Ackermann, Daniel; Vogt, Bruno and Mohaupt, Markus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0306-4530

Publisher:

Elsevier

Language:

English

Submitter:

Nasser Dhayat

Date Deposited:

20 Apr 2016 12:54

Last Modified:

09 Sep 2017 07:54

Publisher DOI:

10.1016/j.psyneuen.2016.02.003

PubMed ID:

26881833

Uncontrolled Keywords:

Allostatic load, heritability, physiological dysregulation, population-based, socioeconomic status

BORIS DOI:

10.7892/boris.78886

URI:

https://boris.unibe.ch/id/eprint/78886

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