The CCR2/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain

Andres, Robert H; Choi, Raymond; Pendharkar, Arjun V; Gaeta, Xavier; Wang, Nancy; Nathan, Jaya K; Chua, Joshua Y; Lee, Star W; Palmer, Theo D; Steinberg, Gary K; Guzman, Raphael (2011). The CCR2/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain. Stroke, 42(10), pp. 2923-31. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/STROKEAHA.110.606368

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The inflammatory response is a critical component of ischemic stroke. In addition to its physiological role, the mechanisms behind transendothelial recruitment of immune cells also offer a unique therapeutic opportunity for translational stem cell therapies. Recent reports have demonstrated homing of neural stem cells (NSC) into the injured brain areas after intravascular delivery. However, the mechanisms underlying the process of transendothelial recruitment remain largely unknown. Here we describe the critical role of the chemokine CCL2 and its receptor CCR2 in targeted homing of NSC after ischemia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Andres, Robert

ISSN:

0039-2499

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

17 Mar 2015 21:02

Publisher DOI:

10.1161/STROKEAHA.110.606368

PubMed ID:

21836091

Web of Science ID:

000295217100052

URI:

https://boris.unibe.ch/id/eprint/7891 (FactScience: 213266)

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