1D.03: Inactive Matrix Gla Protein is Assocated with Renal Resistive Index in a Population-Based Study

Pivin, E; Pruijm, M; Ackermann, Daniel; Guessous, I; Ehret, G; Pechère-Bertschi, A; Paccaud, F; Mohaupt, Markus; Vermeer, C; Staessen, J A; Vogt, Bruno; Martin, P; Burnier, M; Bochud, M; Ponte, B (2015). 1D.03: Inactive Matrix Gla Protein is Assocated with Renal Resistive Index in a Population-Based Study. Journal of hypertension, 33(Suppl 1), e15. Lippincott Williams & Wilkins 10.1097/01.hjh.0000467389.43721.16

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OBJECTIVE Renal resistive index (RRI) varies directly with renal vascular stiffness and pulse pressure. RRI correlates positively with arteriolosclerosis in damaged kidneys and predicts progressive renal dysfunction. Matrix Gla-protein (MGP) is a vascular calcification inhibitor that needs vitamin K to be activated. Inactive MGP, known as desphospho-uncarboxylated MGP (dp-ucMGP), can be measured in plasma and has been associated with various cardiovascular (CV) markers, CV outcomes and mortality. In this study we hypothesize that increased RRI is associated with high levels of dp-ucMGP. DESIGN AND METHOD We recruited participants via a multi-center family-based cross-sectional study in Switzerland exploring the role of genes and kidney hemodynamics in blood pressure regulation. Dp-ucMGP was quantified in plasma samples by sandwich ELISA. Renal doppler sonography was performed using a standardized protocol to measure RRIs on 3 segmental arteries in each kidney. The mean of the 6 measures was reported. Multiple regression analysis was performed to estimate associations between RRI and dp-ucMGP adjusting for sex, age, pulse pressure, mean pressure, renal function and other CV risk factors. RESULTS We included 1035 participants in our analyses. Mean values were 0.64 ± 0.06 for RRI and 0.44 ± 0.21 (nmol/L) for dp-ucMGP. RRI was positively associated with dp-ucMGP both before and after adjustment for sex, age, body mass index, pulse pressure, mean pressure, heart rate, renal function, low and high density lipoprotein, smoking status, diabetes, blood pressure and cholesterol lowering drugs, and history of CV disease (P < 0.001). CONCLUSIONS RRI is independently and positively associated with high levels of dp-ucMGP after adjustment for pulse pressure and common CV risk factors. Further studies are needed to determine if vitamin K supplementation can have a positive effect on renal vascular stiffness and kidney function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Ackermann, Daniel; Mohaupt, Markus and Vogt, Bruno

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0263-6352

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Markus Georg Mohaupt

Date Deposited:

29 Feb 2016 15:28

Last Modified:

01 Aug 2016 02:30

Publisher DOI:

10.1097/01.hjh.0000467389.43721.16

PubMed ID:

26102738

BORIS DOI:

10.7892/boris.78911

URI:

https://boris.unibe.ch/id/eprint/78911

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