Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease.

Haider, Dominik; Sauter, Thomas; Lindner, Gregor; Masghati, Salome; Peric, Slobodan; Friedl, Alexander; Wolzt, Michael; Hörl, Walter H; Soleiman, Afschin; Exadaktylos, Aristomenis; Fuhrmann, Valentin (2015). Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease. Kidney & blood pressure research, 40(6), pp. 630-637. Karger 10.1159/000368539

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BACKGROUND/AIMS The use of antihypertensive medicines has been shown to reduce proteinuria, morbidity, and mortality in patients with chronic kidney disease (CKD). A specific recommendation for a class of antihypertensive drugs is not available in this population, despite the pharmacodynamic differences. We have therefore analysed the association between antihypertensive medicines and survival of patients with chronic kidney disease. METHODS Out of 2687 consecutive patients undergoing kidney biopsy a cohort of 606 subjects with retrievable medical therapy was included into the analysis. Kidney function was assessed by glomerular filtration rate (GFR) estimation at the time point of kidney biopsy. Main outcome variable was death. RESULTS Overall 114 (18.7%) patients died. In univariate regression analysis the use of alpha-blockers and calcium channel antagonists, progression of disease, diabetes mellitus (DM) type 1 and 2, arterial hypertension, coronary heart disease, peripheral vascular disease, male sex and age were associated with mortality (all p<0.05). In a multivariate Cox regression model the use of calcium channel blockers (HR 1.89), age (HR 1.04), DM type 1 (HR 8.43) and DM type 2 (HR 2.17) and chronic obstructive pulmonary disease (HR 1.66) were associated with mortality (all p < 0.05). CONCLUSION The use of calcium channel blockers but not of other antihypertensive medicines is associated with mortality in primarily GN patients with CKD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Haider, Dominik; Sauter, Thomas; Lindner, Gregor and Exadaktylos, Aristomenis

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1423-0143

Publisher:

Karger

Language:

English

Submitter:

Romana Saredi

Date Deposited:

12 Apr 2016 07:44

Last Modified:

12 Apr 2016 07:44

Publisher DOI:

10.1159/000368539

PubMed ID:

26672999

BORIS DOI:

10.7892/boris.79081

URI:

https://boris.unibe.ch/id/eprint/79081

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