Magnesium in cystic fibrosis - Systematic review of the literature

Santi, Maristella; Milani, Gregorio P; Simonetti, Giacomo; Fossali, Emilio F; Bianchetti, Mario G; Lava, Sebastiano (2016). Magnesium in cystic fibrosis - Systematic review of the literature. Pediatric pulmonology, 51(2), pp. 196-202. Wiley-Blackwell 10.1002/ppul.23356

[img] Text
ppul23356.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (302kB)

BACKGROUND

The metabolism of sodium, potassium, and chloride and the acid-base balance are sometimes altered in cystic fibrosis. Textbooks and reviews only marginally address the homeostasis of magnesium in cystic fibrosis.

METHODS

We performed a search of the Medical Subject Headings terms (cystic fibrosis OR mucoviscidosis) AND (magnesium OR hypomagnes[a]emia) in the US National Library of Medicine and Excerpta Medica databases.

RESULTS

We identified 25 reports dealing with magnesium and cystic fibrosis. The results of the review may be summarized as follows. First, hypomagnesemia affects more than half of the cystic fibrosis patients with advanced disease; second, magnesemia, which is normally age-independent, relevantly decreases with age in cystic fibrosis; third, aminoglycoside antimicrobials frequently induce both acute and chronic renal magnesium-wasting; fourth, sweat magnesium concentration was normal in cystic fibrosis patients; fifth, limited data suggest the existence of an impaired intestinal magnesium balance. Finally, stimulating observations suggest that magnesium supplements might achieve an improvement in respiratory muscle strength and mucolytic activity of both recombinant and endogenous deoxyribonuclease.

CONCLUSIONS

The first comprehensive review of the literature confirms that, despite being one of the most prevalent minerals in the body, the importance of magnesium in cystic fibrosis is largely overlooked. In these patients, hypomagnesemia should be sought once a year. Furthermore, the potential of supplementation with this cation deserves more attention.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Simonetti, Giacomo, Lava, Sebastiano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

8755-6863

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

02 May 2016 10:47

Last Modified:

05 Dec 2022 14:53

Publisher DOI:

10.1002/ppul.23356

PubMed ID:

26663706

Uncontrolled Keywords:

aminoglycosides; cystic fibrosis; hypomagnesemia; magnesium; review

BORIS DOI:

10.7892/boris.79312

URI:

https://boris.unibe.ch/id/eprint/79312

Actions (login required)

Edit item Edit item
Provide Feedback