Schlapbach, Luregn J; Giannoni, Eric; Wellmann, Sven; Stocker, Martin; Ammann, Roland; Graf, Rolf (2015). Normal values for pancreatic stone protein in different age groups. BMC anesthesiology, 15(168), p. 168. BioMed Central 10.1186/s12871-015-0149-y
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BACKGROUND
Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP.
METHODS
PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations.
RESULTS
PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %).
CONCLUSIONS
This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Ammann, Roland |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1471-2253 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
08 Apr 2016 09:44 |
Last Modified: |
05 Dec 2022 14:53 |
Publisher DOI: |
10.1186/s12871-015-0149-y |
PubMed ID: |
26588901 |
BORIS DOI: |
10.7892/boris.79318 |
URI: |
https://boris.unibe.ch/id/eprint/79318 |
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