Outcomes after early administration of plasma exchange in pediatric central nervous system inflammatory demyelination.

Bigi, Sandra; Banwell, Brenda; Yeh, E Ann (2015). Outcomes after early administration of plasma exchange in pediatric central nervous system inflammatory demyelination. Journal of child neurology, 30(7), pp. 874-880. Decker 10.1177/0883073814545883

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The use of plasma exchange has been described in steroid-refractory central nervous system inflammatory demyelination in adults, but less has been published regarding its use in children and adolescents. We describe 12 children treated with plasma exchange for acute severe central nervous system inflammatory demyelination. The clinical attack leading to plasma exchange included symptomatic spinal cord lesions in 10 and symptomatic brainstem lesions in 2 children. Diagnosis was acute transverse myelitis in 6, relapsing-remitting multiple sclerosis in 5, and acute disseminated encephalomyelitis in 1 child. Adverse events related to plasma exchange necessitating intervention were observed in 3 children. Median Expanded Disability Status Scale score at plasma exchange start was 7.5 (range 4-9.5). At 3 months, 7 children were ambulatory without aid (Expanded Disability Status Scale score of ≤4). This retrospective study suggests that plasma exchange can be effective in ameliorating symptoms in severe pediatric central nervous system inflammatory demyelination, although lack of randomization or control group limits the ability to attribute this outcome entirely to plasma exchange.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Bigi, Sandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0883-0738

Publisher:

Decker

Language:

English

Submitter:

André Schaller

Date Deposited:

07 Apr 2016 16:53

Last Modified:

07 Apr 2016 16:53

Publisher DOI:

10.1177/0883073814545883

PubMed ID:

25246301

Uncontrolled Keywords:

central nervous system inflammatory demyelination; pediatric; plasma exchange

BORIS DOI:

10.7892/boris.79321

URI:

https://boris.unibe.ch/id/eprint/79321

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