Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them?

Bosemani, Thangamadhan; Steinlin, Maja; Toelle, Sandra P; Beck, Jürgen; Boltshauser, Eugen; Huisman, Thierry A G M; Poretti, Andrea (2016). Pseudotumoral hemicerebellitis as a mimicker of Lhermitte-Duclos disease in children: does neuroimaging help to differentiate them? Child's nervous system, 32(5), pp. 865-871. Springer 10.1007/s00381-015-2977-y

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The clinical presentation and neuroimaging findings of children with pseudotumoral hemicerebellitis (PTHC) and Lhermitte-Duclos disease (LDD) may be very similar. The differentiation between these entities, however, is important because their management and prognosis are different. We report on three children with PTHC. For all three children, in the acute situation, the differentiation between PTHC and LDD was challenging. A review of the literature shows that a detailed evaluation of conventional and neuroimaging data may help to differentiate between these two entities. A striated folial pattern, brainstem involvement, and prominent veins surrounding the thickened cerebellar foliae on susceptibility weighted imaging favor LDD, while post-contrast enhancement and an increased choline peak on (1)H-Magnetic resonance spectroscopy suggest PTHC.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Steinlin, Maja and Beck, Jürgen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0256-7040

Publisher:

Springer

Language:

English

Submitter:

André Schaller

Date Deposited:

11 Apr 2016 15:07

Last Modified:

20 Sep 2017 17:06

Publisher DOI:

10.1007/s00381-015-2977-y

PubMed ID:

26649682

Uncontrolled Keywords:

Children Imaging Lhermitte-Duclos disease Pseudotumoral hemicerebellitis

BORIS DOI:

10.7892/boris.79371

URI:

https://boris.unibe.ch/id/eprint/79371

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