PP080. First trimester umbilical artery end-diastolic flow and pulsatility index: Comparison between preeclampsia and control.

Zdanowicz, Jarmila Anna; Tappeser, Priska; Lengsfeld, Michael; Baumann, Marc Ulrich; Hofstaetter, Cornelia; Surbek, Daniel; Raio, Luigi (2013). PP080. First trimester umbilical artery end-diastolic flow and pulsatility index: Comparison between preeclampsia and control. Pregnancy hypertension, 3(2), pp. 96-97. Elsevier 10.1016/j.preghy.2013.04.105

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INTRODUCTION The appearance of end-diastolic flow velocities (EDF) in the umbilical artery (UA), usually between 10 and 14 weeks of gestation, has been associated with the opening of the spiral arteries and consequently of the intervillous space. OBJECTIVES The aim of our study was to compare first trimester UA pulsatility index (PI) and EDF between women who developed preeclampsia (cases) and controls. METHODS Our database was searched for cases who had UA Doppler between 10-14 weeks. UA PI and EDF were compared between cases and two gestational age (GA) matched controls. RESULTS 15 cases with severe preeclampsia (PE) were matched to 30 controls. GA with negative EDF was lower than with positive EDF (12.1±0.79 vs. 12.8±0.34; p=0.001). UA PI in cases was higher than in controls, although not significant (cases: 2.18±0.6 vs. CONTROLS 1.92±0.48; p=0.12). However, comparing groups with negative EDF, the difference became significant (PI cases: 2.45±0.57 vs. PI controls: 1.94±0.56; p=0.038), while no difference was found comparing groups with positive EDF. CONCLUSION First trimester UA PI is significantly higher in women which will develop PE than in controls. Interestingly, the timing of screening for PE by UA Doppler seems to play an important issue.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Zdanowicz, Jarmila Anna; Tappeser, Priska; Lengsfeld, Michael; Baumann, Marc Ulrich; Hofstaetter, Cornelia; Surbek, Daniel and Raio, Luigi

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2210-7789

Publisher:

Elsevier

Language:

English

Submitter:

Monika Zehr

Date Deposited:

02 May 2016 15:47

Last Modified:

01 Oct 2019 14:52

Publisher DOI:

10.1016/j.preghy.2013.04.105

PubMed ID:

26105934

BORIS DOI:

10.7892/boris.79448

URI:

https://boris.unibe.ch/id/eprint/79448

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