Interplay between cardiac function and heart development

Andrés-Delgado, Laura; Mercader Huber, Nadia (2016). Interplay between cardiac function and heart development. Biochimica et biophysica acta - molecular cell research, 1863(7), pp. 1707-1716. Elsevier 10.1016/j.bbamcr.2016.03.004

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Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Develomental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Mercader Huber, Nadia

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0167-4889

Publisher:

Elsevier

Language:

English

Submitter:

Nadia Isabel Mercader Huber

Date Deposited:

30 Jun 2016 16:37

Last Modified:

29 May 2017 17:20

Publisher DOI:

10.1016/j.bbamcr.2016.03.004

PubMed ID:

26952935

Uncontrolled Keywords:

Blood and pericardial flow; Cardiac development; Mechanosensing; Mechanotransduction; Mouse; Zebrafish

BORIS DOI:

10.7892/boris.79610

URI:

https://boris.unibe.ch/id/eprint/79610

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