The Epicardium in the Embryonic and Adult Zebrafish

Peralta, Marina; González-Rosa, Juan Manuel; Marques, Inês Joao; Mercader Huber, Nadia (2014). The Epicardium in the Embryonic and Adult Zebrafish. Journal of developmental biology, 2(2), pp. 101-116. MDPI 10.3390/jdb2020101

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The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Mercader Huber, Nadia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2221-3759

Publisher:

MDPI

Language:

English

Submitter:

Nadia Isabel Mercader Huber

Date Deposited:

09 Jun 2016 16:27

Last Modified:

19 Jun 2016 10:09

Publisher DOI:

10.3390/jdb2020101

PubMed ID:

24926432

Uncontrolled Keywords:

development epicardium proepicardium regeneration wt1a wt1b zebrafish

BORIS DOI:

10.7892/boris.79615

URI:

https://boris.unibe.ch/id/eprint/79615

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