[Lineage tracing of epicardial cells during development and regeneration].

González-Rosa, Juan Manuel; Padrón-Barthe, Laura; Torres, Miguel; Mercader Huber, Nadia (2010). [Lineage tracing of epicardial cells during development and regeneration]. Revista española de cardiología, 63(Suppl2), pp. 36-48. Elsevier

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Tracing the history of individual cells during embryonic morphogenesis in a structure as complex as the cardiovascular system is one of the major challenges of developmental biology. It involves determining the relationships between the various lineages of cells forming an organ at different stages, describing the topological rearrangements tissues undergo during morphogenesis, and characterizing the interactions between cells in different structures. However, despite the great expectations raised in the field of regenerative medicine, only limited progress has been made in using regenerative therapy to repair the cardiovascular system. Recent research has highlighted the role of the epicardium during cardiac regeneration, but it is still unclear whether it is important for molecular signaling or acts as a source of progenitor cells during this process. Consequently, increasing knowledge about the origin, diversification and potential of epicardial cells during development and homeostasis and under pathological conditions is of fundamental importance both for basic research and for the development of effective cellular therapies. The aims of this article were to provide a general overview of the classical techniques used for tracing cell lineages, including their potential and limitations, and to describe novel techniques for studying the origin and differentiation of the epicardium and its role in cardiac regeneration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Mercader Huber, Nadia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1579-2242

Publisher:

Elsevier

Language:

English

Submitter:

Nadia Isabel Mercader Huber

Date Deposited:

20 May 2016 15:14

Last Modified:

20 May 2016 15:14

PubMed ID:

20540899

URI:

https://boris.unibe.ch/id/eprint/79623

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