Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes.

Mercader Huber, Nadia; Leonardo, E; Piedra, M E; Martínez-A, C; Ros, M A; Torres, M (2000). Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development, 127(18), pp. 3961-3970. Company of Biologists Limited

Preview

Text 3961.full.pdf - Published Version Available under License Publisher holds Copyright. Download (396kB) | Preview

Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.

Interest & Impact

Downloads

567 since deposited on 30 Jun 2016
62 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item