Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus

Weber de Melo, Vanessa; Sheikh Ali, Hanan; Freise, Jona; Kühnert, Denise; Essbauer, Sandra; Mertens, Marc; Wanka, Konrad M.; Drewes, Stephan; Ulrich, Rainer G.; Heckel, Gerald (2015). Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus. Evolutionary applications, 8(6), pp. 545-559. Wiley 10.1111/eva.12263

[img]
Preview
Text
Evol Appl.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (745kB) | Preview

Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations, but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Population Genetics
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Weber de Melo, Vanessa and Heckel, Gerald

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1752-4571

Publisher:

Wiley

Language:

English

Submitter:

Isabelle Duperret

Date Deposited:

04 May 2016 11:00

Last Modified:

05 Jul 2017 16:55

Publisher DOI:

10.1111/eva.12263

PubMed ID:

26136821

BORIS DOI:

10.7892/boris.79906

URI:

https://boris.unibe.ch/id/eprint/79906

Actions (login required)

Edit item Edit item
Provide Feedback