Maharjan, Niran; Saxena, Smita (2016). ER strikes again: Proteostasis Dysfunction In ALS. EMBO journal, 35(8), pp. 798-800. Nature Publishing Group 10.15252/embj.201694117
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The precise contribution of endoplasmic reticulum (ER) chaperone protein disulfide isomerase (PDI) variants in human amyotrophic lateral sclerosis (ALS) patients to the pathogenesis of ALS remained unclear. In the present study, Woehlbier et al (2016) demonstrated that these PDI variants
are capable of altering motor neuron morphology, impairing the expression of synaptic proteins, and compromising neuromuscular junction (NMJ) integrity.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Maharjan, Niran, Saxena, Smita |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0261-4189 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Prof. Smita Saxena |
Date Deposited: |
09 May 2016 15:55 |
Last Modified: |
05 Dec 2022 14:54 |
Publisher DOI: |
10.15252/embj.201694117 |
PubMed ID: |
26968985 |
BORIS DOI: |
10.7892/boris.79961 |
URI: |
https://boris.unibe.ch/id/eprint/79961 |
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