ER strikes again: Proteostasis Dysfunction In ALS

Maharjan, Niran; Saxena, Smita (2016). ER strikes again: Proteostasis Dysfunction In ALS. EMBO journal, 35(8), pp. 798-800. Nature Publishing Group 10.15252/embj.201694117

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The precise contribution of endoplasmic reticulum (ER) chaperone protein disulfide isomerase (PDI) variants in human amyotrophic lateral sclerosis (ALS) patients to the pathogenesis of ALS remained unclear. In the present study, Woehlbier et al (2016) demonstrated that these PDI variants are capable of altering motor neuron morphology, impairing the expression of synaptic proteins, and compromising neuromuscular junction (NMJ) integrity.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Maharjan, Niran and Saxena, Smita

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0261-4189

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Prof. Smita Saxena

Date Deposited:

09 May 2016 15:55

Last Modified:

09 May 2016 15:55

Publisher DOI:

10.15252/embj.201694117

PubMed ID:

26968985

BORIS DOI:

10.7892/boris.79961

URI:

https://boris.unibe.ch/id/eprint/79961

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