Expanded Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Multimodal Imaging

Marsiglia, M; Gallego-Pinazo, R; Cunha de Souza, E; Munk, Marion; Mrejen, S; Cunningham, ET; Lujan, BJ; Goldberg, NR; Albini, TA; Gaudric, A; Francais, C; Rosen, R; Freund, BK; Jampol, LM; Yannuzzi, LA (2016). Expanded Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Multimodal Imaging. Retina - the journal of retinal and vitreous diseases, 36(1), pp. 64-74. Lippincott, Williams & Wilkins 10.1097/IAE.0000000000000685

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PURPOSE: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities. METHODS: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence. RESULTS: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography. CONCLUSION: Multimodal imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion


600 Technology > 610 Medicine & health




Lippincott, Williams & Wilkins




Marion Munk

Date Deposited:

11 May 2016 12:44

Last Modified:

01 Feb 2017 02:30

Publisher DOI:


PubMed ID:






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