Evaluation of coagulation and fibrinolysis in horses with atrial fibrillation

Navas de Solís, Cristobal; Reef, Virginia B.; Slack, JoAnn; Jose-Cunilleras, Eduard (2016). Evaluation of coagulation and fibrinolysis in horses with atrial fibrillation. Journal of the American Veterinary Medical Association, 248(2), pp. 201-206. American Veterinary Medical Association 10.2460/javma.248.2.201

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OBJECTIVE To evaluate horses with atrial fibrillation for hypercoagulability; plasma D-dimer concentrations, as a marker of a procoagulant state; and a relationship between coagulation profile results and duration of atrial fibrillation or presence of structural heart disease. DESIGN Case-control study. ANIMALS Plasma samples from 42 horses (25 with atrial fibrillation and 17 without cardiovascular or systemic disease [control group]). PROCEDURES Results of hematologic tests (ie, plasma fibrinogen and D-dimer concentrations, prothrombin and activated partial thromboplastin times, and antithrombin activity) in horses were recorded to assess coagulation and fibrinolysis. Historical and clinical variables, as associated with a hypercoagulable state in other species, were also recorded. RESULTS Horses with atrial fibrillation and control horses lacked clinical signs of hypercoagulation or thromboembolism. Compared with control horses, horses with atrial fibrillation had significantly lower antithrombin activity. No significant differences in plasma fibrinogen and D-dimer concentrations and prothrombin and activated partial thromboplastin times existed between horse groups. In horses with atrial fibrillation versus control horses, a significantly larger proportion had an abnormal plasma D-dimer concentration (10/25 vs 2/17), test results indicative of subclinical activated coagulation (18/25 vs 6/17), or abnormal coagulation test results (25/121 vs 7/85), respectively. CONCLUSIONS AND CLINICAL RELEVANCE Horses with atrial fibrillation did not have clinical evidence of a hypercoagulable state, but a higher proportion of horses with atrial fibrillation, compared with control horses, did have subclinical activated coagulation on the basis of standard coagulation test results.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Navas de Solís, Cristobal

Subjects:

600 Technology > 630 Agriculture

ISSN:

0003-1488

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

31 Mar 2016 10:15

Last Modified:

10 Sep 2017 16:18

Publisher DOI:

10.2460/javma.248.2.201

PubMed ID:

26720087

BORIS DOI:

10.7892/boris.80099

URI:

https://boris.unibe.ch/id/eprint/80099

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