Does superficial fat affect metabolite concentrations determined by MR spectroscopy with water referencing?

Kyathanahally, Sreenath Pruthviraj; Fichtner, Nicole Damara; Adalid López, Víctor Javier; Kreis, Roland (2015). Does superficial fat affect metabolite concentrations determined by MR spectroscopy with water referencing? NMR in biomedicine, 28(11), pp. 1543-1549. Wiley Interscience 10.1002/nbm.3419

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It has recently been reported in this journal that local fat depots produce a sizable frequency-dependent signal attenuation in magnetic resonance spectroscopy (MRS) of the brain. If of a general nature, this effect would question the use of internal reference signals for quantification of MRS and the quantitative use of MRS as a whole. Here, it was attempted to verify this effect and pinpoint the potential causes by acquiring data with various acquisition settings, including two field strengths, two MR scanners from different vendors, different water suppression sequences, RF coils, localization sequences, echo times, and lipid/metabolite phantoms. With all settings tested, the reported effect could not be reproduced, and it is concluded that water referencing and quantitative MRS per se remain valid tools under common acquisition conditions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Kyathanahally, Sreenath Pruthviraj; Fichtner, Nicole Damara; Adalid López, Víctor Javier and Kreis, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0952-3480

Publisher:

Wiley Interscience

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

13 Apr 2016 16:23

Last Modified:

20 Jul 2017 09:19

Publisher DOI:

10.1002/nbm.3419

PubMed ID:

26423456

Uncontrolled Keywords:

MRS; brain; fat; quantification

BORIS DOI:

10.7892/boris.80125

URI:

https://boris.unibe.ch/id/eprint/80125

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