Campos, Vanessa; Despland, Camille; Brandejsky, Vaclav; Kreis, Roland; Schneiter, Philippe; Chiolero, Arnaud; Boesch, Christoph Hans; Tappy, Luc (2015). Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial. Obesity, 23(12), pp. 2335-2339. Wiley 10.1002/oby.21310
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OBJECTIVE
To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar-sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption.
METHODS
About 31 healthy subjects with BMI greater than 25 kg/m(2) and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL).
RESULTS
About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers.
CONCLUSIONS
In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Brandejsky, Vaclav, Kreis, Roland, Boesch, Christoph Hans |
ISSN: |
1930-7381 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Christoph Hans Boesch |
Date Deposited: |
11 Apr 2016 16:41 |
Last Modified: |
05 Dec 2022 14:54 |
Publisher DOI: |
10.1002/oby.21310 |
PubMed ID: |
26727115 |
BORIS DOI: |
10.7892/boris.80128 |
URI: |
https://boris.unibe.ch/id/eprint/80128 |
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