Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial.

Campos, Vanessa; Despland, Camille; Brandejsky, Vaclav; Kreis, Roland; Schneiter, Philippe; Chiolero, Arnaud; Boesch, Christoph Hans; Tappy, Luc (2015). Sugar- and artificially sweetened beverages and intrahepatic fat: A randomized controlled trial. Obesity, 23(12), pp. 2335-2339. Wiley 10.1002/oby.21310

[img] Text
oby21310.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (137kB) | Request a copy

OBJECTIVE To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar-sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption. METHODS About 31 healthy subjects with BMI greater than 25 kg/m(2) and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL). RESULTS About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers. CONCLUSIONS In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Brandejsky, Vaclav; Kreis, Roland and Boesch, Christoph Hans








Christoph Hans Boesch

Date Deposited:

11 Apr 2016 16:41

Last Modified:

11 Apr 2016 16:41

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback