Diffusion tensor imaging of the human kidney: Does image registration permit scanning without respiratory triggering?

Seif, Maryam; Mani, Laila-Yasmin; Lu, Huanxiang; Boesch, Christoph Hans; Reyes, Mauricio; Vogt, Bruno; Vermathen, Peter (2016). Diffusion tensor imaging of the human kidney: Does image registration permit scanning without respiratory triggering? Journal of magnetic resonance imaging, 44(2), n/a-n/a. Wiley Interscience 10.1002/jmri.25176

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PURPOSE To investigate if image registration of diffusion tensor imaging (DTI) allows omitting respiratory triggering for both transplanted and native kidneys MATERIALS AND METHODS: Nine kidney transplant recipients and eight healthy volunteers underwent renal DTI on a 3T scanner with and without respiratory triggering. DTI images were registered using a multimodal nonrigid registration algorithm. Apparent diffusion coefficient (ADC), the contribution of perfusion (FP ), and the fractional anisotropy (FA) were determined. Relative root mean square errors (RMSE) of the fitting and the standard deviations of the derived parameters within the regions of interest (SDROI ) were evaluated as quality criteria. RESULTS Registration significantly reduced RMSE in all DTI-derived parameters of triggered and nontriggered measurements in cortex and medulla of both transplanted and native kidneys (P < 0.05 for all). In addition, SDROI values were lower with registration for all 16 parameters in transplanted kidneys (14 of 16 SDROI values were significantly reduced, P < 0.04) and for 15 of 16 parameters in native kidneys (9 of 16 SDROI values were significantly reduced, P < 0.05). Comparing triggered versus nontriggered DTI in transplanted kidneys revealed no significant difference for RMSE (P > 0.14) and for SDROI (P > 0.13) of all parameters. In contrast, in native kidneys relative RMSE from triggered scans were significantly lower than those from nontriggered scans (P < 0.02), while SDROI was slightly higher in triggered compared to nontriggered measurements in 15 out of 16 comparisons (significantly for two, P < 0.05). CONCLUSION Registration improves the quality of DTI in native and transplanted kidneys. Diffusion parameters in renal allografts can be measured without respiratory triggering. In native kidneys, respiratory triggering appears advantageous. J. Magn. Reson. Imaging 2016.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Seif, Maryam; Mani, Laila-Yasmin; Lu, Huanxiang; Boesch, Christoph Hans; Reyes, Mauricio; Vogt, Bruno and Vermathen, Peter

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1053-1807

Publisher:

Wiley Interscience

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

30 May 2016 08:56

Last Modified:

17 Jul 2016 02:05

Publisher DOI:

10.1002/jmri.25176

PubMed ID:

26871263

Uncontrolled Keywords:

DTI; diffusion; kidney; motion correction; nonrigid image registration; respiratory triggering

BORIS DOI:

10.7892/boris.80130

URI:

https://boris.unibe.ch/id/eprint/80130

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