High-dose intravenous immunoglobulins: A promising therapeutic approach for idiopathic systemic capillary leak syndrome

Zipponi, Manuel; Eugster, Roland; Birrenbach, Tanja (2011). High-dose intravenous immunoglobulins: A promising therapeutic approach for idiopathic systemic capillary leak syndrome. BMJ case reports, 2011 London: BMJ Publishing Group 10.1136/bcr.12.2010.3599

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The systemic capillary leak syndrome (SCLS), also known as Clarkson’s disease, is a life-threatening disorder of unknown cause. It is characterised by recurrent acute episodes of hypotension, weight gain and generalised oedema with haemoconcentration and hypoproteinaemia caused by paroxysmal capillary hyperpermeability with a shift of plasma fluid from the intravascular to the interstitial space. We report the case of a 40-year-old woman with chronic SCLS treated with high-dose intravenous immunoglobulins, after a prophylactic therapy with theophylline and terbutaline was poorly tolerated and failed to decrease the frequency and severity of the attacks sufficiently.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

Birrenbach, Tanja Nicole

ISSN:

1757-790X

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

28 Oct 2016 13:06

Publisher DOI:

10.1136/bcr.12.2010.3599

PubMed ID:

22696704

URI:

https://boris.unibe.ch/id/eprint/8022 (FactScience: 213436)

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