Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD).

de Beer, Dirk; Völzmann, Jan; Kalka, Christoph; Baerlocher, Gabriela M. (2015). Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD). Journal of clinical and diagnostic research : JCDR, 9(3), OM01-OM03. Premchand Shantidevi Research Foundation 10.7860/JCDR/2015/10931.5684

[img] Text
GMB_jcdr-9-OM01.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (328kB) | Request a copy

Telomere attrition has been linked to accelerate vascular ageing and seems to predispose for vascular disease. Our aim was to study the telomere length dynamics over time and in subsets of leukocytes from 15 patients with peripheral arterial disease (PAD). The mean telomere length in subsets of leukocytes of patients with PAD was in the normal range of age-related telomere length values from healthy individuals. However, we found significant higher telomere attrition for T-cells from patients with PAD over a time period of six months when compared to the controls. The higher telomere loss in T-cells of patients with PAD most likely reflects a higher cell turnover of this leukocyte subset, which is involved in the process of chronic inflammatory disease underlying vascular disease. Further studies are needed to confirm these data and to assess how far this T-cell telomere attrition will correlate to the extent of the disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)

UniBE Contributor:

Baerlocher, Gabriela M.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2249-782X

Publisher:

Premchand Shantidevi Research Foundation

Language:

English

Submitter:

Verena Zwahlen

Date Deposited:

24 Mar 2016 13:13

Last Modified:

24 Mar 2016 13:13

Publisher DOI:

10.7860/JCDR/2015/10931.5684

PubMed ID:

25954657

Uncontrolled Keywords:

Arteriosclerosis; CAD; PAD; Telomere length

BORIS DOI:

10.7892/boris.80283

URI:

https://boris.unibe.ch/id/eprint/80283

Actions (login required)

Edit item Edit item
Provide Feedback