Parker, Kaveri S; Wilson, James D; Marschall, Jonas; Mucha, Peter J; Henderson, Jeffrey P (2015). Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens. ACS infectious diseases, 1(11), pp. 523-532. American Chemical Society 10.1021/acsinfecdis.5b00022
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Increasing antibiotic resistance among uropathogenic Escherichia coli (UPEC) is driving interest in therapeutic targeting of nonconserved virulence factor (VF) genes. The ability to formulate efficacious combinations of antivirulence agents requires an improved understanding of how UPEC deploy these genes. To identify clinically relevant VF combinations, we applied contemporary network analysis and biclustering algorithms to VF profiles from a large, previously characterized inpatient clinical cohort. These mathematical approaches identified four stereotypical VF combinations with distinctive relationships to antibiotic resistance and patient sex that are independent of traditional phylogenetic grouping. Targeting resistance- or sex-associated VFs based upon these contemporary mathematical approaches may facilitate individualized anti-infective therapies and identify synergistic VF combinations in bacterial pathogens.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Marschall, Jonas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2373-8227 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
12 Apr 2016 16:51 |
Last Modified: |
05 Dec 2022 14:54 |
Publisher DOI: |
10.1021/acsinfecdis.5b00022 |
PubMed ID: |
26985454 |
Uncontrolled Keywords: |
UPEC; UTI; antibiotic resistance; network analysis; novel therapeutic targets; sex specificity in infections; uropathogens |
BORIS DOI: |
10.7892/boris.80310 |
URI: |
https://boris.unibe.ch/id/eprint/80310 |
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